Robertson E P, Pollock A, Yau K S, Chan L C
Department of Pathology, University of Hong Kong, Queen Mary Hospital Compound.
Med Lab Sci. 1992 Dec;49(4):259-64.
In a retrospective study of 36 cases of alpha-thalassaemia trait, 43 cases of beta-thalassaemia trait and 45 cases of iron deficiency, we have assessed the performance of the Technicon H1 erythrogram, the hypochromia minus microcytosis (H-M) index, and the discriminant function (DF). The diagnostic accuracy of the erythrogram pattern was 83.3% for alpha-thalassaemia trait and 95.3% for beta-thalassaemia trait. The diagnostic accuracy for the H-M index was 19.4% for alpha-thalassaemia trait, 72.1% for beta-thalassaemia trait and 91.1% for iron deficiency. By comparison, the DF gave a diagnostic accuracy of 75.0% for alpha-thalassaemia trait, 81.4% for beta-thalassaemia trait and 88.9% for iron deficiency when using a locally derived value for the constant (k) = 19.2. Our study shows that the H1 erythrogram pattern, the H-M index and the DF are useful predictive indicators in routine laboratory screening for thalassaemia.
在一项对36例α地中海贫血特征患者、43例β地中海贫血特征患者和45例缺铁患者的回顾性研究中，我们评估了Technicon H1红细胞图、低色素减去小红细胞（H-M）指数和判别函数（DF）的性能。红细胞图模式对α地中海贫血特征的诊断准确率为83.3%，对β地中海贫血特征的诊断准确率为95.3%。H-M指数对α地中海贫血特征的诊断准确率为19.4%，对β地中海贫血特征的诊断准确率为72.1%，对缺铁的诊断准确率为91.1%。相比之下，当使用本地得出的常数（k）=19.2时，DF对α地中海贫血特征的诊断准确率为75.0%，对β地中海贫血特征的诊断准确率为81.4%，对缺铁的诊断准确率为88.9%。我们的研究表明，H1红细胞图模式、H-M指数和DF是地中海贫血常规实验室筛查中有用的预测指标。
