CIRAD-EMVT, Maisons-Alfort, France.
Rev Elev Med Vet Pays Trop. 1992;45(3-4):235-40.
A freeze-dried virus vaccine against Newcastle's disease was prepared using the heat tolerant derivative V4/276 of the virus strain V4 (UPM). The viral mean titre was 10(10.4) EID50 per vial after 14 days at +4 degrees C and 10(10) EID50 after 126 days. Incubation at 45 degrees C for 7 and 14 days reduced the titre to 10(8.5) and 10(8.2) EID50, respectively. In addition, this preparation was exposed to ambient temperature at Ouagadougou (Burkina Faso) during the first fortnight of July 1991 when the temperature ranged from 25 to 32 degrees C, but never exceeded 35 degrees C. After 7 and 14 days of storage, the viral mean titre was 10(9.3) EID50 per vial. This vaccine is intended to coat grains fed to African village chickens.
一种针对新城疫的冻干病毒疫苗，使用病毒株V4（马来西亚博特拉大学）的耐热衍生物V4/276制备。在4摄氏度下保存14天后，每瓶病毒平均滴度为10(10.4) EID50，126天后为10(10) EID50。在45摄氏度下孵育7天和14天，滴度分别降至10(8.5)和10(8.2) EID50。此外，1991年7月的头两周，该制剂在布基纳法索瓦加杜古暴露于环境温度下，当时温度在25至32摄氏度之间，但从未超过35摄氏度。储存7天和14天后，每瓶病毒平均滴度为10(9.3) EID50。这种疫苗旨在包裹喂给非洲乡村鸡的谷物。
