Yerbanga E, Demandiere J M, Mercier P
CIRAD-EMVT, Maisons-Alfort, France.
Rev Elev Med Vet Pays Trop. 1996;49(4):279-83.
Vaccination against Newcastle disease with the thermotolerant LaSota/A300 and V4/276 coated-millet vaccines was tried in Ouagadougou, Burkina Faso, by feeding 298 European broiler chickens exhibiting maternal antibodies. Opportunistic infections, such as colibacteriosis, decimated 70-81% of the three vaccinated groups and 24% of control, before being eradicated by antibiotic therapy. The surviving chickens were challenged two months after vaccination with the Hertz 33/56 virus strain. This resulted in 100% deaths in the control group, 78% in birds vaccinated with the V4/276, 7% in birds fed with LaSota/A300, and in no death in the group given both vaccines at one week interval. These last two groups also exhibited high titres of 1HA antibodies before the challenge. The lyophilized LaSota/A300 and V4/276 vaccines kept high viral titres after 8-34 days' ambient temperature exposure during the cool season in Ouagadougou.
在布基纳法索的瓦加杜古，通过给298只携带母源抗体的欧洲肉鸡投喂耐热的拉索塔/A300和V4/276包衣小米疫苗，尝试进行新城疫疫苗接种。诸如大肠杆菌病等机会性感染，在三组接种疫苗的鸡中致使70%-81%的鸡死亡，对照组中24%的鸡死亡，之后通过抗生素治疗得以根除。存活的鸡在接种疫苗两个月后用赫兹33/56病毒株进行攻毒。这导致对照组100%的鸡死亡，接种V4/276疫苗的鸡78%死亡，投喂拉索塔/A300的鸡7%死亡，而间隔一周接种两种疫苗的组中没有鸡死亡。在攻毒前，最后这两组也表现出高滴度的1HA抗体。在瓦加杜古凉爽季节，冻干的拉索塔/A300和V4/276疫苗在室温下暴露8-34天后仍保持高病毒滴度。
