Kowalczyk-Bronisz S, Giełdanowski J, Bubak B, Kotz J
Department of Immunopharmacology, Polish Academy of Sciences, Wrocław.
Arch Immunol Ther Exp (Warsz). 1992;40(5-6):283-9.
The effect of organophosphate pesticide--Chlorfenwinfos on the selected parameters of humoral and cellular immunologic response in mice was investigated. Hematologic and histologic examinations were run parallelly. The animals were treated with pesticide p.o. during 90 days in doses 1/100, 1/50 and 1/25 of LD50. It was found that Chlorfenwinfos exerts immunotropic effect. After high doses the strong suppressive effect in PFC and EA rosettes was observed. Significant involution of thymus was noted. Il-1 activity, DTH reaction (24 h after challenge) and endogenous and exogenous spleen colonies were stimulated. It seems that immunotropic effect of this pesticide is reversible. Three weeks after the exposure to this compound had been stopped, PFC, IgG and IgM level came back to the normal value.
研究了有机磷农药毒虫畏对小鼠体液和细胞免疫反应选定参数的影响。同时进行了血液学和组织学检查。动物经口给予农药，持续90天，剂量为LD50的1/100、1/50和1/25。发现毒虫畏具有免疫调节作用。高剂量后，观察到对PFC和EA花环有强烈的抑制作用。胸腺明显萎缩。IL-1活性、DTH反应（攻击后24小时）以及内源性和外源性脾集落受到刺激。这种农药的免疫调节作用似乎是可逆的。停止接触该化合物三周后，PFC、IgG和IgM水平恢复到正常水平。
