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重组人肿瘤坏死因子（rh-TNFα）对体外培养的粒-巨噬细胞祖细胞（CFU-GM）和白血病克隆形成原始细胞（CFU-L）的影响。

The influence of recombinant human tumor necrosis factor (rh-TNF alpha) on granulocyte-macrophage progenitor cells (CFU-GM) and clonogenic leukaemic blasts (CFU-L) in cultures in vitro.

作者信息

Robak T, Korycka A, Góra-Tybor J, Piotrowska-Wrzesień A, Krykowski E

机构信息

2nd Clinic of Internal Medicine, Medical Academy, Lódź, Poland.

出版信息

Arch Immunol Ther Exp (Warsz). 1992;40(5-6):339-43.

PMID:1340192
Abstract

We investigated the influence of recombinant human tumor necrosis factor alfa (rh-TNF alpha) on the clonal growth of CFU-GM from 14 normal individuals and clonogenic blasts (CFU-L) from 16 patients with acute myeloid leukaemia (AML) in semi-solid cultures in vitro. Recombinant human TNF was produced by the Center of Molecular and Macromolecular Studies of the Polish Academy of Sciences (Lódź, Poland) as a lyophylized powder. This factor was added to the culture medium at the concentrations of 10, 100, 1000 U/ml. A dose-dependent growth inhibition of CFU-GM and AML CFU-L was observed. The inhibitory effect of rh-TNF alpha was significantly greater on CFU-L than CFU-GM.

摘要

我们在体外半固体培养中研究了重组人肿瘤坏死因子α（rh-TNFα）对14名正常个体的粒-巨噬细胞集落形成单位（CFU-GM）以及16名急性髓系白血病（AML）患者的克隆形成母细胞（CFU-L）克隆生长的影响。重组人TNF由波兰科学院分子与大分子研究中心（波兰罗兹）生产，为冻干粉末。该因子以10、100、1000 U/ml的浓度添加到培养基中。观察到CFU-GM和AML CFU-L呈剂量依赖性生长抑制。rh-TNFα对CFU-L的抑制作用明显大于对CFU-GM的抑制作用。

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