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The effect of lithium chloride on granulocyte-macrophage progenitor cells (CFU-GM) and clonogenic leukaemic blasts (CFU-L) in the cultures in vitro.

作者信息

Korycka A, Robak T

机构信息

Department of Clinical Pharmacology, Copernicus Hospital, Medical Academy, Lódź, Poland.

出版信息

Arch Immunol Ther Exp (Warsz). 1991;39(5-6):495-500.

PMID:1668709
Abstract

The influence of lithium chloride on the proliferation of normal granulocyte-macrophage progenitor cells (CFU-GM) and clonogenic blasts (CFU-L) from patients with acute myeloid leukaemia in the semisolid cultures in vitro was investigated. It was observed that while lithium chloride with the concentration of 2 mmol/l increases the number of CFU-GM colonies, it does not increase the number of CFU-L colonies and clusters. Our studies indicate that lithium salts can be used for the treatment of patients with acute myeloid leukaemia after intensive chemotherapy.

摘要

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