Michaelis G, Somlo M
J Bioenerg. 1976 Apr;8(2):93-107. doi: 10.1007/BF01558631.
Different mitochondrial mutants have been isolated that affect mitochondrial ribosome function. These mutants were used to establish most of the known methods and principles of mitochondrial genetics in yeast. Another class of mitochondrial mutants have been shown to affect mitochondrial ATPase and, more specifically, the "membrane factor" of mitochondrial ATPase. These mutants might be very useful in studying the energy-conserving function, and the interaction between the hydrophobic and hydrophylic parts, of the ATPase complex. New types of mitochondrial point mutations, concerning cytochrome a-a3 or b, will soon open up new fields of investigation. The biochemical and genetic analysis of numerous mutants belonging to that category and recently obtained [31] is being currently pursued in Tzagoloff's and Slonimski's laboratories.
已分离出不同的线粒体突变体，它们影响线粒体核糖体功能。这些突变体被用于建立酵母中线粒体遗传学的大多数已知方法和原理。另一类线粒体突变体已被证明会影响线粒体ATP酶，更具体地说，会影响线粒体ATP酶的“膜因子”。这些突变体在研究ATP酶复合体的能量守恒功能以及疏水部分与亲水部分之间的相互作用方面可能非常有用。关于细胞色素a-a3或b的新型线粒体点突变，将很快开辟新的研究领域。Tzagoloff和Slonimski的实验室目前正在对属于该类别的众多最近获得的突变体[31]进行生化和遗传分析。
