Malone T A, Stonestreet B S, Goddard M, Sicard R, Werner J C, Oh W
Department of Pediatrics, Women & Infants' Hospital of Rhode Island, Providence 02905.
Dev Pharmacol Ther. 1992;19(2-3):155-60. doi: 10.1159/000457477.
Atrial natriuretic peptide (ANP) is a hormone involved in fluid and blood pressure homeostasis. We studied the effects of left-to-right shunting through a patent ductus arteriosus on blood pressure changes and plasma ANP concentrations in newborn piglets. In five experimental piglets, the ductus arteriosus was bathed with PGE1 and infiltrated with formalin to maintain its patency. In four age-matched control piglets, the ductus arteriosus was ligated. Plasma ANP concentrations and blood pressure determinations were obtained prior to (base-line) and 25 +/- 1 h (day 1), and 48 +/- 1 h (day 2) after surgery. Radionuclide-microsphere determinations of left-to-right patent ductus arteriosus shunts were performed on days 1 and 2 in the 5 piglets with a patent ductus arteriosus. Plasma ANP concentrations were significantly elevated in the left atrium on day 1 and the right atrium on day 2 in the PDA piglets. No correlation was demonstrated between plasma ANP concentrations and right or left atrial pressures. We conclude that left and right plasma atrial ANP concentrations are significantly elevated in newborn piglets with left-to-right patent ductus arteriosus shunts.
心钠素（ANP）是一种参与体液和血压稳态调节的激素。我们研究了通过未闭动脉导管的左向右分流对新生仔猪血压变化和血浆心钠素浓度的影响。在5只实验仔猪中，用前列腺素E1灌注动脉导管并用福尔马林浸润以维持其通畅。在4只年龄匹配的对照仔猪中，结扎动脉导管。在手术前（基线）、术后25±1小时（第1天）和48±1小时（第2天）测定血浆心钠素浓度和血压。对5只患有未闭动脉导管的仔猪在第1天和第2天进行放射性核素微球测定左向右未闭动脉导管分流情况。在患有动脉导管未闭的仔猪中，第1天左心房和第2天右心房的血浆心钠素浓度显著升高。血浆心钠素浓度与右心房或左心房压力之间未显示出相关性。我们得出结论，在患有左向右未闭动脉导管分流的新生仔猪中，左、右血浆心钠素浓度显著升高。
