Heitkemper M M, Bond E F, Gruver M K, Horita A
Department of Physiological Nursing, University of Washington, Seattle 98195.
Dev Pharmacol Ther. 1992;19(2-3):57-61. doi: 10.1159/000457465.
Intracisternal injection of thyrotropin-releasing hormone (TRH) increases gastric motility primarily via a vagal cholinergic mechanism. However, a serotonergic (5-HT) component may also exist. Rats (7, 10, 14, and > or = 50 days of age) were anesthetized and gastric motility monitored via an extraluminal strain gauge. Following baseline, ICS 205-930 which blocks 5-HT3 and 5-HT4 receptors (0.01, 0.10, or 1.0 mg/kg) was administered intraperitoneally, then 30 min later intracisternal TRH (5 or 10 micrograms). ICS 205-930 0.1 and 1.0 mg/kg blocked TRH-induced motility in 7-day-old rats. Results support a 5-HT3 or 5-HT4 receptor contribution to TRH-induced gastric motility stimulation, and suggest that receptor expression is dynamic during development.
向脑池内注射促甲状腺激素释放激素（TRH）主要通过迷走胆碱能机制增强胃动力。然而，可能也存在5-羟色胺能（5-HT）成分。将不同日龄（7日龄、10日龄、14日龄和≥50日龄）的大鼠麻醉，并通过腔外应变仪监测胃动力。在记录基线水平后，腹腔注射阻断5-HT3和5-HT4受体的ICS 205-930（0.01、0.10或1.0mg/kg），30分钟后向脑池内注射TRH（5或10μg）。0.1mg/kg和1.0mg/kg的ICS 205-930可阻断7日龄大鼠中TRH诱导的胃动力。结果支持5-HT3或5-HT4受体在TRH诱导的胃动力刺激中发挥作用，并表明受体表达在发育过程中是动态变化的。
