Cuperlović M
Institute for the Application of Nuclear Energy, INEP, Zemun.
Glas Srp Akad Nauka Med. 1992(42):19-35.
Lectins defined as proteins other than enzymes and antibodies that possess binding sites for specific carbohydrate sequences, are associated with the cell surface, the cytoplasm, the nucleus, extracellular matrices and body fluids, and are involved in molecular recognition, trafficking of glycoproteins and tissue organisation. Animal lectins are classified into two main groups: the C-type and the S-type lectins, characterised by sequence homology, solubility, sugar specificity, distribution, developmental regulation, calcium-dependency and reducing agents-dependency for their saccharide binding activity. Under SANU Projects supervised by Academician Milovan Jovanović, lectin types C and S were investigated. Special emphasis was placed on asialoglycoprotein receptor of rat hepatocytes, soluble beta-galactoside-binding protein of human placenta and hepatic nuclear lectins. The results of this work are presented and discussed hereinafter.
凝集素被定义为除酶和抗体之外具有特定碳水化合物序列结合位点的蛋白质，它们与细胞表面、细胞质、细胞核、细胞外基质和体液相关，并参与分子识别、糖蛋白运输和组织构建。动物凝集素主要分为两类：C型和S型凝集素，其特征在于序列同源性、溶解性、糖特异性、分布、发育调控、钙依赖性以及其糖结合活性对还原剂的依赖性。在米洛万·约万诺维奇院士监督的SANU项目中，对C型和S型凝集素进行了研究。特别强调了大鼠肝细胞的去唾液酸糖蛋白受体、人胎盘的可溶性β-半乳糖苷结合蛋白和肝核凝集素。以下将展示并讨论这项工作的结果。
