Fink N E
Departamento de Ciencias Biológicas, Universidad Nacional de la Plata, Argentina.
Acta Physiol Pharmacol Ther Latinoam. 1996;46(1):1-10.
Animal lectins are classified on the basis of structural and functional studies in two types: the C-type, characterized by their dependence on calcium ions and the S-type which are not calcium-dependent, but thiol-dependent. In this late one, a group has been extensively studied as the S-Lac type. They are extracted with saline buffers added with lactose in presence of thiol agents, and constitute a family of structurally related protein which contain a series of conserved amino acids. They specifically bind to complementary glicoconjugates, and their biosynthesis and localization are developmentally regulated. Their role could be related to several biological activities in different organs.
C型，其特征是依赖钙离子；S型，不依赖钙离子，而是依赖硫醇。在后者中，有一组被广泛研究为S-Lac型。它们在硫醇试剂存在的情况下，用添加乳糖的盐缓冲液提取，构成一个结构相关的蛋白质家族，其中包含一系列保守氨基酸。它们特异性地结合互补的糖缀合物，其生物合成和定位受发育调控。它们的作用可能与不同器官中的几种生物活性有关。
