Moreira E S, Guerra J B, Petrillo-Peixoto M de L
Departamento de Microbiologia, Universidade Federal de Minas Gerais, Belo Horizonte.
Rev Soc Bras Med Trop. 1992 Oct-Dec;25(4):247-50. doi: 10.1590/s0037-86821992000400006.
Growth inhibition in vitro tests were used to study the susceptibility to pentostam of different Leishmania strains involved in cutaneous and mucocutaneous leishmaniasis--one glucantime sensitive strain, three naturally glucantime resistant strains and one glucantime resistant line developed by in vitro drug exposure. Contrasting with the high degree of glucantime resistance, all strains were sensitive to pentostam. These differences suggest that there is some relationship between chemical structure and in vitro activity for these antimonial compounds. These data justify a clinical re-evaluation to compare therapeutic efficacy of glucantime and pentostam in the treatment of leishmaniasis.
体外生长抑制试验用于研究参与皮肤和黏膜皮肤利什曼病的不同利什曼原虫菌株对喷他脒的敏感性——一株对葡糖胺锑钠敏感的菌株、三株天然对葡糖胺锑钠耐药的菌株以及一株通过体外药物暴露培养出的对葡糖胺锑钠耐药的细胞株。与高度的葡糖胺锑钠耐药性形成对比的是，所有菌株对喷他脒均敏感。这些差异表明这些锑化合物的化学结构与体外活性之间存在某种关联。这些数据为临床重新评估以比较葡糖胺锑钠和喷他脒在治疗利什曼病方面的疗效提供了依据。
