Moreira E S, Soares R M, Petrillo-Peixoto M de L
Departamento de Microbiologia, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Parasitol Res. 1995;81(4):291-5. doi: 10.1007/BF00931532.
Growth inhibition of Leishmania promastigotes by glucantime was compared in three different media. Glucantime inhibited the growth of Leishmania cultured in complex medium but did not affect parasite growth when added to cells cultured in defined or semi-defined media. Supplementation of the complex medium with biopterin partially reversed the glucantime effect in sensitive strains, although the addition of folic acid or oleic acid did not alter the activity of glucantime. Differences in fatty acid composition were observed between strains showing different degrees of glucantime susceptibility.
在三种不同培养基中比较了葡甲胺对利什曼原虫前鞭毛体的生长抑制作用。葡甲胺抑制在复合培养基中培养的利什曼原虫的生长，但添加到在限定或半限定培养基中培养的细胞时，对寄生虫生长没有影响。向复合培养基中添加生物蝶呤可部分逆转敏感菌株中葡甲胺的作用，尽管添加叶酸或油酸不会改变葡甲胺的活性。在对葡甲胺敏感性不同的菌株之间观察到脂肪酸组成的差异。
