Abram M, Brue T, Morange I, Girard N, Guibout M, Jaquet P
Service d'Endocrinologie, C.H.U. Nord, Marseille.
Ann Endocrinol (Paris). 1992;53(5-6):215-23.
We studied 7 women with primary hypothyroidism who were suspected to harbor a prolactinoma on the basis of a pituitary gland enlargement associated with hyperprolactinemia. The diagnosis of prolactinoma was confirmed in 1 case only, which was treated surgically. In the remaining 6 patients the serum prolactin levels fell to normal on thyroxine replacement therapy and reduction in size of the pituitary gland was demonstrated by neuroradiological imaging in the 3 documented cases. This study underlines the fact that hyperprolactinemia associated with pituitary hyperplasia is secondary to hypothyroidism and that thyroid function tests should be obtained in all hyperprolactinemic patients even those with pituitary enlargement.
我们研究了7例原发性甲状腺功能减退症女性患者，她们因垂体增大并伴有高催乳素血症而被怀疑患有催乳素瘤。仅1例确诊为催乳素瘤，并接受了手术治疗。其余6例患者在接受甲状腺素替代治疗后血清催乳素水平降至正常，3例有记录的病例经神经放射学成像显示垂体体积缩小。本研究强调了这样一个事实，即与垂体增生相关的高催乳素血症继发于甲状腺功能减退症，所有高催乳素血症患者，即使是垂体增大的患者，都应进行甲状腺功能检查。
