Dichi J B, Dichi I, Papini-Berto S J, Bicudo M H, Angeleli A Y, Rezende T A, Burini R C
Departamento de Clínica Médica e Enfermana da Disciplina de Gastroenterologia, Faculdade de Medicina de Botucatú, Universidade Estadual Paulista, UNESP.
Arq Gastroenterol. 1992 Oct-Dec;29(4):128-36.
The dietary protein assimilation by cirrhotic undernourished patients (lower lean body mass and plasma TBPA and RBP levels) was investigated in five-adult male subjects suffering from histologically diagnosed liver cirrhosis, in its clinically mild stage (Child-Turcotte-Pugh grade A). During the 9 day-dietary study the patients received orally a sequence of complete-regional diets containing different protein-energy compositions identified as (g prot/Cal/kg/day): D0 = 0.42/20.9; D1 = 0.91/37.5; D2 = 0.99/47.9 and D3 = 1.60/40.5. The respective N-balance values (g/day) found were (mean +/- SD): low protein calorie (D0) = -4.24 +/- 2.46; normal protein calorie (D1) = 0.66 +/- 1.99; normal protein-high calorie (D2) = 1.14 +/- 2.54; high protein normal calorie (D3) = 5.12 +/- 2.48. The correspondent urea-N output (g/kg/day) were D0 = 0.22 +/- 0.100; D1 = 0.238 +/- 0.099; D = 0.20 +/- 0.063 and D3 = 0.310 +/- 0.121. The present data thus suggest that protein rather than energy intake would be the limited factor for increasing the N-retention in (mild) cirrhotic patients whom tolerate well dietary protein at either normal or elevated levels.
对五名经组织学诊断为肝硬化且处于临床轻度阶段（Child-Turcotte-Pugh A级）的成年男性患者（瘦体重、血浆转甲状腺素蛋白和视黄醇结合蛋白水平较低）的膳食蛋白质同化情况进行了研究。在为期9天的饮食研究中，患者口服一系列全区域饮食，这些饮食含有不同的蛋白质-能量组成，分别为（克蛋白质/千卡/千克/天）：D0 = 0.42/20.9；D1 = 0.91/37.5；D2 = 0.99/47.9和D3 = 1.60/40.5。所发现的相应氮平衡值（克/天）为（平均值±标准差）：低蛋白热量（D0）= -4.24±2.46；正常蛋白热量（D1）= 0.66±1.99；正常蛋白-高热量（D2）= 1.14±2.54；高蛋白正常热量（D3）= 5.12±2.48。相应的尿素氮输出（克/千克/天）分别为D0 = 0.22±0.100；D1 = 0.238±0.099；D2 = 0.20±0.063和D3 = 0.310±0.121。因此，目前的数据表明，对于（轻度）肝硬化患者，蛋白质而非能量摄入可能是增加氮潴留的限制因素，这些患者对正常或升高水平的膳食蛋白质耐受性良好。
