Kida Yohei
Department of Internal Medicine, Kainan Municipal Hospital, Kainan City, Japan.
Scand J Gastroenterol. 2009;44(5):615-8. doi: 10.1080/00365520802699252.
Evaluation of protein intake of patients with liver cirrhosis (LC) would facilitate optimal nutritional support. However, this has never been done based on urinary urea nitrogen (UUN). The aim of this study was to determine the usefulness of the estimated protein intake (EPI) based on UUN in patients with LC.
Eighty-two patients with LC were enrolled in this study. The actual protein intake (API) was defined as the dietary protein intake (1.0 g/kg/day) plus supplementation of any enteral diets containing branched-chain amino acids (BCAA). We calculated EPI from UUN using the formula [(UUN (g/day) + 0.031 x body-weight (kg)) x0.625]. We examined the correlation between EPI and API and the EPI/API ratio (EAR), and the correction based on the results.
A significant positive correlation was found between API and EPI (r=0.72, p<0.001). The EAR in all patients was 0.82+/-0.13. EPI x 1.2 was the correction needed to adjust EAR to 1. The corrected EPI was correlated with API (r=0.704, p<0.001). The corrected EAR of all 82 patients was 0.99+/-0.16.
EPI calculated from UUN is a useful tool for optimal nutritional support in LC patients, and our correction greatly improves EPI accuracy.
评估肝硬化（LC）患者的蛋白质摄入量将有助于实现最佳营养支持。然而，从未基于尿尿素氮（UUN）进行过此类评估。本研究的目的是确定基于UUN的估计蛋白质摄入量（EPI）在LC患者中的实用性。
本研究纳入了82例LC患者。实际蛋白质摄入量（API）定义为膳食蛋白质摄入量（1.0 g/kg/天）加上补充任何含支链氨基酸（BCAA）的肠内饮食。我们使用公式[（UUN（克/天）+0.031×体重（千克））×0.625]从UUN计算EPI。我们检查了EPI与API之间的相关性以及EPI/API比率（EAR），并根据结果进行校正。
发现API与EPI之间存在显著正相关（r = 0.72，p < 0.001）。所有患者的EAR为0.82±0.13。将EAR调整至1所需的校正值为EPI×1.2。校正后的EPI与API相关（r = 0.704，p < 0.001）。82例患者校正后的EAR为0.99±0.16。
根据UUN计算的EPI是LC患者最佳营养支持的有用工具，我们的校正大大提高了EPI的准确性。
