三种短链肽（α-促黑素、促黑素/促肾上腺皮质激素4-10、促黑素抑制因子-1）对维度注意的影响。

Influence of three short-chain peptides (alpha-MSH, MSH/ACTH 4-10, MIF-I on) dimensional attention.

作者信息

Beckwith B E, Sandman C A, Kastin A

出版信息

Pharmacol Biochem Behav. 1976;5(Suppl 1):11-6. doi: 10.1016/0091-3057(76)90322-1.

Abstract

Male, albino rats were treated with alpha-MSH, MSH/ACTH 4-10, MIF-I or a diluent control solution and then tested on a visual discrimination problem. Immediately after acquistion of the visual task the animals were tested with a spatial extradimensional shift problem. The animals treated with the MSH/ACTH 4-10 and MIF-I acquired the discrimination nonsignificantly faster than animals treated with alpha-MSH or a placebo. A subproblem analysis of the EDS behavior indicated that the peptides significantly improved performance probably by affecting attention.

摘要

雄性白化大鼠接受了α-促黑素、促黑素/促肾上腺皮质激素4-10、促黑素抑制因子-1或稀释对照溶液的处理，然后进行视觉辨别问题测试。在习得视觉任务后，立即对动物进行空间维度外转换问题测试。接受促黑素/促肾上腺皮质激素4-10和促黑素抑制因子-1处理的动物比接受α-促黑素或安慰剂处理的动物获得辨别能力的速度略快，但无显著差异。对维度外转换行为的子问题分析表明，这些肽可能通过影响注意力显著改善了表现。