Barbeau A, Gonce M, Kastin A J
Pharmacol Biochem Behav. 1976;5(Suppl 1):159-63. doi: 10.1016/0091-3057(76)90346-4.
This paper reviews recent evidence that a number of small peptides found in the brain are active in the central nervous system and behaviorally. Attention is focused on MSH/ACTH 4-10, alpha- and beta-MSH, and the prohormone beta-LPH, as they produce a syndrome of yawning and stretching. Studies with substance P and mainly with MIF-I are also reviewed. It is shown that substance P is an excitatory transmitter or modulator in the dorsal spinal cord with that MIF-I has antiparkinson properties. It is concluded that many polypeptides have direct actions on the central nervous system independent of their neuroendocrine properties.
本文综述了近期的证据，这些证据表明在大脑中发现的一些小肽在中枢神经系统和行为方面具有活性。重点关注促黑素/促肾上腺皮质激素4-10、α-和β-促黑素以及前激素β-促脂素，因为它们会产生打哈欠和伸展的综合征。本文还综述了有关P物质以及主要是促黑素释放抑制因子-1的研究。结果表明，P物质是脊髓背角的一种兴奋性递质或调节剂，促黑素释放抑制因子-1具有抗帕金森病特性。得出的结论是，许多多肽对中枢神经系统具有直接作用，而与其神经内分泌特性无关。
