Brahm J, Hurtado C, Latorre R
Centro de Gastroenterología, Hospital Clínico Universidad de Chile, Santiago.
Rev Med Chil. 1992 Aug;120(8):862-5.
Pre S2 was investigated using a monoclonal ELISA in 100 samples from 52 patients with different forms of infection with Hepatitis B virus. Pre S2 was present in 18 of 19 patients with acute hepatitis. Its persistence for more than 150 days after beginning of symptoms was associated to a chronic hepatitis state. It was also present in 11 patients with chronic hepatitis or cirrhosis, 15 asymptomatic Hepatitis B carriers and 3 of 4 patients with hepatic carcinoma. Pre S2 became negative in only 1 of 3 patients treated with interferon who had a positive response according to HBe and HBs antigens. Thus, Pre S2 is present in patients with evidence of viral replication. It is more a marker of persistent Hepatitis B infection than of chronic liver damage.
采用单克隆酶联免疫吸附测定法（ELISA）对52例患有不同形式乙肝病毒感染患者的100份样本进行前S2检测。19例急性肝炎患者中有18例存在前S2。症状出现后持续超过150天与慢性肝炎状态相关。11例慢性肝炎或肝硬化患者、15例无症状乙肝携带者以及4例肝癌患者中的3例也存在前S2。在3例接受干扰素治疗且根据HBe和HBs抗原显示有阳性反应的患者中，只有1例前S2转为阴性。因此，前S2存在于有病毒复制证据的患者中。它更多是持续性乙肝感染的标志物，而非慢性肝损伤的标志物。
