Brahm J, Hurtado C, Elgueta S, Fuentes C, Velásquez A
Centro de Gastroenterología Hospital Clínico Universidad de Chile, Santiago de Chile.
Rev Med Chil. 1995 May;123(5):567-70.
Pre S1 antigen was measured using an ELISA technique in patients with different forms of hepatitis B virus infection. It was detected in 10 of 19 patients with acute hepatitis B (53%), 12 of 15 chronic hepatitis B virus carriers (80%), 9 of 11 patients with chronic hepatitis B (82%) and 3 of 4 patients with hepatoma and positive markers of hepatitis B virus infection. Pre S1 remained positive beyond 150 days in two patients with acute hepatitis that evolved to chronicity. Among subjects with chronic hepatitis B that received interferon, pre S1 antigen negativized only in the patient that had a complete response. Pre S1 detection is an index of hepatitis B virus replication and its persistence determines chronicity. Its negativization after antiviral therapy should have a predictive value.
采用酶联免疫吸附测定（ELISA）技术检测不同形式乙肝病毒感染患者的前S1抗原。在19例急性乙型肝炎患者中有10例检测到该抗原（53%），15例慢性乙肝病毒携带者中有12例（80%），11例慢性乙型肝炎患者中有9例（82%），以及4例肝癌且乙肝病毒感染标志物呈阳性的患者中有3例检测到该抗原。两名急性乙型肝炎演变为慢性肝炎的患者，其前S1抗原在150天后仍为阳性。在接受干扰素治疗的慢性乙型肝炎患者中，仅完全缓解的患者前S1抗原转阴。前S1抗原检测是乙肝病毒复制的一个指标，其持续存在决定了慢性化。抗病毒治疗后其转阴应具有预测价值。
