Valente M, Minarini M, Ius P, Talenti E, Bortolotti U, Milano A, Thiene G
University of Padua Medical School, Italy.
J Heart Valve Dis. 1992 Nov;1(2):216-24.
Bovine pericardium has been widely employed as a xenograft tissue for the manufacture of bioprosthetic valve substitutes. Early three-leaflet valve models showed poor tissue preservation and shortcomings in valve design, which accounted for tissue wear and prosthesis failure due to cuspal tear. Reducing the number of cusps in the unicusp pericardial valve has proved unsuccessful due to stretching of the single pericardial leaflet with consequent valvular incompetence. The new generation of pericardial xenografts present basic changes in valve design and optimal tissue preservation after industrial processing, with no evidence of leaflet tear at medium term follow up. However, clinical experience is limited and, similarly to porcine xenografts, dystrophic calcification still appears to be a major problem.
牛心包已被广泛用作制造生物人工心脏瓣膜替代品的异种移植组织。早期的三叶瓣模型显示出组织保存不佳以及瓣膜设计存在缺陷，这导致了组织磨损和因瓣叶撕裂而造成的假体失效。由于单个心包瓣叶的拉伸以及随之而来的瓣膜功能不全，减少单叶心包瓣膜的瓣叶数量已被证明是不成功的。新一代心包异种移植物在瓣膜设计上有了根本性的改变，并且在经过工业加工后能实现最佳的组织保存，在中期随访中没有瓣叶撕裂的迹象。然而，临床经验有限，并且与猪异种移植物类似，营养不良性钙化似乎仍然是一个主要问题。
