Zioupos P, Barbenel J C, Fisher J
Department of Biology, University of York, UK.
J Biomed Mater Res. 1994 Jan;28(1):49-57. doi: 10.1002/jbm.820280107.
Uniaxial tensile tests were performed on glutaraldehyde fixed bovine pericardial strips prepared from chemically modified pericardial samples. These samples originated from an area which demonstrated anisotropic mechanical properties in the native material and which is suitable for the construction of leaflets for pericardial bioprostheses. After glutaraldehyde fixation the tissue had retained its anisotropicity in stiffness and strength in two orthogonal directions. In the range of the functional stresses for a heart valve leaflet (< 1 MPa) the unconstrained fixation regime had modified the initial anisotropic elastic behavior into a more isotropic one. The implications of these findings are that leaflets manufactured from bovine pericardium can be made to resemble, to a degree, the well known anisotropy found in two orthogonal directions in natural human heart valve leaflets, or porcine bioprosthetic heart valve leaflets.
对由化学改性心包样本制备的戊二醛固定牛心包条进行单轴拉伸试验。这些样本取自天然材料中表现出各向异性力学性能且适合构建心包生物瓣膜小叶的区域。戊二醛固定后，组织在两个正交方向上的刚度和强度仍保持各向异性。在心脏瓣膜小叶功能应力范围（<1MPa）内，无约束固定方式已将初始各向异性弹性行为转变为更具各向同性的行为。这些发现的意义在于，由牛心包制成的小叶在一定程度上可以类似于天然人类心脏瓣膜小叶或猪生物瓣膜心脏瓣膜小叶在两个正交方向上众所周知的各向异性。
