Cañas P, Hernández A, Pérez H
Institute of Nutrition and Food Technology (INTA), University of Chile, Santiago.
Int J Neurosci. 1992 Jul-Aug;65(1-4):141-5. doi: 10.3109/00207459209003285.
Modulatory influences of taurine on cortical visual evoked responses and their susceptibility to GABAergic and glycinergic antagonists were studied in adult rats. Taurine topically administered to the visual cortex produced dose-dependent inhibition of the positive-negative fast component of the cortical visual evoked responses. Neither bicuculline nor strychnine antagonized the taurine effect, as revealed by absence of a shift to right, a change in slope or in the taurine IC50 value in the dose-response curve. Results suggest that taurine-induced depression of cortical responses evoked in the visual cortex are mediated by receptors other than the GABAA and glycine receptors.
在成年大鼠中研究了牛磺酸对皮层视觉诱发电位的调节作用及其对GABA能和甘氨酸能拮抗剂的敏感性。将牛磺酸局部应用于视觉皮层可对皮层视觉诱发电位的正负快速成分产生剂量依赖性抑制。如剂量反应曲线中未出现右移、斜率变化或牛磺酸IC50值变化所示，荷包牡丹碱和士的宁均未拮抗牛磺酸的作用。结果表明，牛磺酸诱导的视觉皮层诱发的皮层反应抑制是由GABAA和甘氨酸受体以外的受体介导的。
