Andrade Z A, Peixoto E
Centro de Pesquisas Gonçalo Moniz (FIOCRUZ), Bahia, Brazil.
Rev Inst Med Trop Sao Paulo. 1992 Jul-Aug;34(4):263-72. doi: 10.1590/s0036-46651992000400001.
Optical and electron microscopical evidences of focal matrix degradation were frequently seen in liver sections of periportal fibrosis caused by schistosomiasis mansoni in man. The material came from 14 wedge hepatic biopsies taken from patients with chronic advanced hepatosplenic disease and undergoing operations for the relief of portal hypertension. Besides the presence of focal areas of rarefaction, fragmentation and dispersion of collagen fibers, the enlarged portal spaces also showed hyperplasia of elastic tissue and disarray of smooth muscle fibers following destruction of portal vein branches. Eggs were scanty in the tissue sections, and matrix degradation probably represented involuting changes related to the progressive diminution of parasite-related aggression, which occurs spontaneously with age or after cure by chemotherapy. The changes indicative of matrix degradation now described are probably the basic morphological counterpart of periportal fibrosis involution currently being documented by ultrasonography in hepatosplenic patients submitted to curative chemotherapy.
在曼氏血吸虫病所致的人肝门周围纤维化的肝切片中，经常可见局灶性基质降解的光学和电子显微镜证据。材料取自14例慢性晚期肝脾疾病患者的楔形肝活检组织，这些患者正在接受手术以缓解门静脉高压。除了存在胶原纤维的局灶性稀疏、断裂和分散外，扩大的门管区还显示出弹性组织增生以及门静脉分支破坏后平滑肌纤维排列紊乱。组织切片中虫卵稀少，基质降解可能代表与寄生虫相关侵袭逐渐减少有关的退化性变化，这种变化会随着年龄增长或化疗治愈后自发发生。目前所描述的表明基质降解的变化可能是目前超声检查记录的接受根治性化疗的肝脾患者肝门周围纤维化退化的基本形态学对应表现。
