Doehring-Schwerdtfeger E, Abdel-Rahim I M, Mohamed-Ali Q, Elsheikh M, Schlake J, Kardorff R, Franke D, Kaiser C, Ehrich J H
Kinderklinik, Medizinische Hochschule Hannover, Federal Republic of Germany.
Am J Trop Med Hyg. 1990 Jun;42(6):581-6. doi: 10.4269/ajtmh.1990.42.581.
Morbidity of Schistosoma mansoni infection was assessed in 536 infected Sudanese schoolchildren using an ultrasonographical staging system for periportal fibrosis of the liver. S. mansoni ova excretion in stools was mild in 28%, moderate in 58%, and severe in 14% of the patients. Grade 1 periportal fibrosis was found in 10.3% grade 2 in 23.1%, and grade 3 in 4.7% of S. mansoni-infected children. Girls and boys were equally affected. The distribution of periportal fibrosis compared to the age of patients was homogenous. There was no significant difference of the rate of periportal fibrosis in the 3 groups of intensity of infection. However, in the 204 patients who showed periportal fibrosis, there was a strong relation between severity of ultrasonographically detectable fibrosis with intensity of egg excretion. In 332 children, of which 73 had a heavy infection, no signs of periportal fibrosis were detected. Sudanese children show a variable susceptibility towards the development of S. mansoni-induced periportal fibrosis. High risk patients can be detected at a childhood stage by measuring the intensity of infection and investigating the liver by ultrasound.
采用肝脏门周纤维化超声分期系统，对536名受曼氏血吸虫感染的苏丹学童的感染发病率进行了评估。患者粪便中曼氏血吸虫卵排泄情况为：轻度占28%，中度占58%，重度占14%。在受曼氏血吸虫感染的儿童中，10.3%有1级门周纤维化，23.1%有2级，4.7%有3级。女孩和男孩受影响程度相同。门周纤维化分布与患者年龄相比是均匀的。三组感染强度的门周纤维化发生率无显著差异。然而，在204例出现门周纤维化的患者中，超声可检测到的纤维化严重程度与虫卵排泄强度之间存在密切关系。在332名儿童中，其中73名感染严重，未检测到门周纤维化迹象。苏丹儿童对曼氏血吸虫诱导的门周纤维化发展表现出不同的易感性。通过测量感染强度和超声检查肝脏，可在儿童期检测出高危患者。
