Dyer A R, Stamler J, Shekelle R B
Department of Community Health and Preventive Medicine, Northwestern University Medical School, Chicago, IL 60611-4402.
Ann Epidemiol. 1992 Jan-Mar;2(1-2):51-7. doi: 10.1016/1047-2797(92)90037-q.
The association of total serum cholesterol with mortality from coronary heart disease was examined in 1210 white men aged 42 to 60 in 1959 to 1963 and 1008 white men aged 45 to 64 in 1959 to 1969, followed up to 25 years from the Chicago Peoples Gas Company Study; in 1903 white men aged 41 to 57 in 1959, followed up to 24 years from the Chicago Western Electric Company Study; and in 17,880 white men aged 25 to 74 and 8327 white women aged 40 to 74 in 1967 to 1973, followed up to 18 years from the Chicago Heart Association Detection Project in Industry. In these studies total cholesterol level was related positively to coronary mortality in young men and in middle-aged and older men and women. Relative risks of mortality were generally higher in young and middle-aged persons compared to older persons, whereas absolute excess risks were generally greater in older than in younger persons.
在1959年至1963年对1210名年龄在42至60岁的白人男性以及1959年至1969年对1008名年龄在45至64岁的白人男性进行了血清总胆固醇与冠心病死亡率之间关联的研究，这些研究来自芝加哥人民燃气公司研究，随访长达25年；在1959年对1903名年龄在41至57岁的白人男性进行了研究，来自芝加哥西部电气公司研究，随访长达24年；在1967年至1973年对17880名年龄在25至74岁的白人男性以及8327名年龄在40至74岁的白人女性进行了研究，来自芝加哥心脏协会工业检测项目，随访长达18年。在这些研究中，总胆固醇水平与年轻男性、中年男性和女性以及老年男性和女性的冠心病死亡率呈正相关。与老年人相比，年轻人和中年人的死亡相对风险通常更高，而绝对超额风险通常在老年人中比在年轻人中更大。
