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[血液透析、强制利尿及解毒剂治疗铊中毒(作者译)]

[Thallium intoxication treated by hemodialysis, forced diuresis and antidote (author's transl)].

作者信息

Barckow J, Jenss H

出版信息

Med Klin. 1976 Aug 27;71(35):1377-82.

PMID:134248
Abstract

Mode of action and toxicity of thallium and former treatment of thallium intoxication are described. A case of thallium poisoning with a lethal dose of thallous sulfate which was successfully treated by hemodialysis, forced diuresis and antidote is reported. 43 percent of the thallium could be eliminated by continuous hemodialysis during 72 hours and forced diuresis within the third and seventh day after ingestion of the poison. The dialysance of thallium was 111,1 ml/min with a blood flow of 200 ml/min. Later damage can be prevented by early maximal elimination of thallium.

摘要

本文描述了铊的作用机制、毒性以及铊中毒的既往治疗方法。报告了一例因摄入致死剂量硫酸亚铊而中毒的病例,该病例通过血液透析、强制利尿和使用解毒剂成功治愈。在摄入毒物后的第三天至第七天,连续72小时的血液透析和强制利尿可清除43%的铊。铊的透析率为111.1毫升/分钟,血流量为200毫升/分钟。早期最大程度地清除铊可预防后期损伤。

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引用本文的文献

1
A fatal case of thallium toxicity: challenges in management.铊中毒致死 1 例:诊治难点。
J Med Toxicol. 2013 Mar;9(1):75-8. doi: 10.1007/s13181-012-0251-1.
2
Pharmacokinetic parameters for thallium (I)-ions in man.
Arch Toxicol. 1983 May;53(1):1-7. doi: 10.1007/BF01459996.
3
An evaluation of the efficacy of charcoal haemoperfusion in the treatment of three cases of acute thallium poisoning.炭血液灌注治疗三例急性铊中毒的疗效评估。
Arch Toxicol. 1985 Apr;57(1):61-6. doi: 10.1007/BF00286577.
4
[The regulation of protein synthesis in heart muscle. Biochemical data, stimulative and inhibitory factors and their clinical significance (author's transl)].[心肌中蛋白质合成的调节。生化数据、刺激和抑制因素及其临床意义(作者译)]
Klin Wochenschr. 1979 Jun 1;57(11):541-53. doi: 10.1007/BF01491133.