Sanz J, Martorell A, Torro I, Carlos Cerda J, Alvarez V
Pediatrics Department, Valencia University, Spain.
J Investig Allergol Clin Immunol. 1992 Jan-Feb;2(1):36-8.
Oral challenge tests were carried out with sodium metabisulfite solution doses of 5, 10, 25, 50 and 100 mg, dissolved in 20 ml of citric acid, and administered to 20 children aged 7-14 years with steroid-dependent bronchial asthma. A single-blind challenge protocol was performed initially and the positive responses were confirmed by double-blind challenge. Initially, 6 of 20 presented a positive reaction, confirmed in 4 of 20 by double-blind challenge. Only 1 child was clinically suspected of exhibiting intolerance to this agent. The prevalence of the challenge test using sodium metabisulfite in children with steroid-dependent bronchial asthma was 20%.
对20名7至14岁依赖类固醇的支气管哮喘患儿进行了口服激发试验，将焦亚硫酸钠溶液剂量分别为5、10、25、50和100毫克溶解于20毫升柠檬酸中后给药。最初采用单盲激发方案，阳性反应通过双盲激发得到确认。最初，20名患儿中有6名出现阳性反应，双盲激发后20名中有4名得到确认。临床上仅怀疑1名儿童对此药物不耐受。依赖类固醇的支气管哮喘患儿使用焦亚硫酸钠进行激发试验的患病率为20%。
