Cantani A, Paganelli R, Meglio P, Ferrara M, Fameles-Belasio E, Businco L
Department of Pediatrics, University of Roma La Sapienza, Italy.
J Investig Allergol Clin Immunol. 1992 Jul-Aug;2(4):181-6.
We evaluated the effect of treatment with flunisolide nasal spray (100 micrograms/day for 3 months) in 24 children with allergic rhinitis on the following parameters: clinical symptoms, absolute number of peripheral and nasal eosinophils, and total IgE levels in nasal secretion. Therapy with flunisolide induced a significant reduction of clinical symptoms (p < 0.001), nasal eosinophils (p < 0.001) and nasal IgE concentration (p < 0.02), while it did not affect the number of peripheral eosinophils. These results indicate that flunisolide can reduce the allergic inflammation of the nasal mucosa.
我们评估了氟尼缩松鼻喷雾剂（每日100微克，持续3个月）对24例变应性鼻炎患儿以下参数的治疗效果：临床症状、外周血及鼻内嗜酸性粒细胞绝对计数以及鼻分泌物中总IgE水平。氟尼缩松治疗使临床症状（p<0.001）、鼻内嗜酸性粒细胞（p<0.001）及鼻内IgE浓度（p<0.02）显著降低，而对外周血嗜酸性粒细胞数量无影响。这些结果表明，氟尼缩松可减轻鼻黏膜的变应性炎症。
