Spector S L, English G, Jones L
J Allergy Clin Immunol. 1980 Aug;66(2):129-37. doi: 10.1016/0091-6749(80)90060-3.
Nasal biopsies of patients with perennial rhinitis were performed at baseline and compared with biopsies performed 4 wk after active flunisolide, 50 micrograms four times per day, or placebo. An effort was made to relate histologic findings to other subjective and objective parameters as an indication of response to treatment. Although patients admitted to the study had severe subjective nasal symptoms, biopsies varied considerably. Some resembled biopsies from normal individuals, and others showed marked edema and inflammation; the latter findings were more typically present in the biopsies of patients with the most severe disease. A decrease in edema and loss of inflammatory cells on biopsy as well as a corresponding decrease in eosinophils on the nasal smear usually accompanied clinical improvement, which occurred in both the active and placebo groups.
对常年性鼻炎患者在基线时进行鼻活检，并与在使用氟尼缩松（每日4次，每次50微克）或安慰剂积极治疗4周后所做的活检进行比较。努力将组织学发现与其他主观和客观参数相关联，作为治疗反应的指标。尽管纳入研究的患者有严重的主观鼻部症状，但活检结果差异很大。一些类似正常个体的活检结果，而另一些则显示出明显的水肿和炎症；后一种发现更典型地出现在病情最严重患者的活检中。活检时水肿减轻和炎症细胞减少，以及鼻涂片上嗜酸性粒细胞相应减少，通常伴随着临床改善，这在活性药物组和安慰剂组中均有发生。
