Murphy D G, DeCarli C, Schapiro M B, Rapoport S I, Horwitz B
Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Bethesda, Md 20892.
Arch Neurol. 1992 Aug;49(8):839-45. doi: 10.1001/archneur.1992.00530320063013.
Magnetic resonance imaging was used to determine the volumes of brain, subcortical gray matter nuclei, and the ventricular and sulcal cerebrospinal fluid in 27 healthy men. Subjects were divided into young (less than 35 years, n = 10) and old (greater than 60 years, n = 17) groups. Volumes were normalized as percent intracranial volume. Older subjects had significantly less brain mass and significantly larger ventricular and peripheral cerebrospinal fluid volumes than the younger men. The caudate and lenticular nuclei were significantly smaller in older than younger men. This significant difference remained when their volumes were expressed as a ratio of cerebral brain matter volume. This cross-sectional study demonstrates age-related atrophy and concurrent dilation of cerebrospinal fluid spaces in healthy subjects. Of brain regions affected, the caudate and lenticular nuclei are significantly more affected by healthy aging than is cerebral brain matter; this may account for some of the motor abnormalities in aging.
利用磁共振成像技术测定了27名健康男性的脑容量、皮质下灰质核团以及脑室和脑沟脑脊液的容量。受试者被分为年轻组（小于35岁，n = 10）和老年组（大于60岁，n = 17）。容量以颅内体积百分比进行标准化。老年受试者的脑质量明显低于年轻男性，脑室和外周脑脊液容量则明显更大。老年男性的尾状核和豆状核明显小于年轻男性。当将它们的体积表示为脑实质体积的比例时，这种显著差异依然存在。这项横断面研究表明，健康受试者中存在与年龄相关的萎缩以及脑脊液间隙的同时扩张。在受影响的脑区中，尾状核和豆状核受健康衰老的影响明显大于脑实质；这可能是衰老过程中一些运动异常的部分原因。
