Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.
Hippocampus. 2009 Nov;19(11):1115-22. doi: 10.1002/hipo.20575.
Visual rating of hippocampal atrophy is often used to differentiate between normal aging and Alzheimer's disease. We investigated whether two visual rating scales of hippocampal atrophy were related to hippocampal volumes, and if visual rating was related to global, cortical and subcortical brain atrophy in persons without dementia. Within the SMART-MR study, a prospective cohort study among patients with manifest arterial disease, medial temporal lobe atrophy was qualitatively rated in 95 participants without dementia (mean age 62 +/- 10 years) using two visual rating scales: the medial temporal lobe (MTA) score was rated on coronal oriented images and the perihippocampal cerebrospinal fluid (HCSF) score was rated on axial oriented images. Hippocampal volume assessed by manual segmentation on a 3-dimensional FFE T1-weighted MR image. Automated segmentation was used to quantify volumes of brain tissue and cerebrospinal fluid. Total brain volume, gray matter volume, and ventricular volume were divided by intracranial volume to obtain brain parenchymal fraction (BPF), gray matter fraction (GMF) and ventricular fraction (VF). Using ANOVA, crude hippocampal volumes were smaller with increasing MTA and HSCF scores as were hippocampal volumes normalized for intracranial volume (P < 0.05). However, hippocampal volumes normalized for total brain size were not smaller with increasing MTA or HSCF scores (P = 0.33 and P = 0.49). Also, with increasing visual rating scores, BPF was smaller and VF was larger (P < 0.001), and the GMF decreased with increasing HCSF score (P = 0.008). In this nondemented population, visual rating of the medial temporal lobe reflects hippocampal atrophy as well as global and subcortical atrophy.
视觉评估海马体萎缩通常用于区分正常衰老和阿尔茨海默病。我们研究了两种视觉评估海马体萎缩的量表是否与海马体体积相关，以及视觉评估是否与无痴呆症的个体的整体、皮质和皮质下脑萎缩相关。在 SMART-MR 研究中，一项针对表现性动脉疾病患者的前瞻性队列研究，对 95 名无痴呆症的参与者（平均年龄 62 +/- 10 岁）进行了内侧颞叶萎缩的定性评估，使用了两种视觉评估量表：基于冠状位图像的内侧颞叶（MTA）评分和基于轴向图像的海马旁脑脊液（HCSF）评分。通过手动分割 3 维 FFE T1 加权 MR 图像评估海马体体积。使用自动分割来量化脑组织和脑脊液的体积。总脑体积、灰质体积和脑室体积除以颅内体积，以获得脑实质分数（BPF）、灰质分数（GMF）和脑室分数（VF）。使用方差分析，随着 MTA 和 HSCF 评分的增加，未校正的海马体体积和校正为颅内体积的海马体体积均减小（P < 0.05）。然而，随着 MTA 或 HSCF 评分的增加，校正为总脑大小的海马体体积并没有变小（P = 0.33 和 P = 0.49）。此外，随着视觉评分的增加，BPF 减小，VF 增大（P < 0.001），并且随着 HCSF 评分的增加，GMF 减少（P = 0.008）。在这个无痴呆症人群中，内侧颞叶的视觉评估反映了海马体萎缩以及整体和皮质下萎缩。
