Briukhin G V, Mikhaĭlova G I
Morfologiia. 1992 Jun;102(6):93-9.
Structural-functional changes to the thymus of progeny of female rats with chronic cholestatic lesions of the liver at different terms of early postnatal ontogeny were investigated. The progeny of this group of animals was found to have less, as compared with controls, mass of the thymus at all periods of the studies, less intensity of the immune reaction of higher sensitivity of the delayed type, less amount of thymocytes of E-RFC. The immunological shifts observed were in close correlation with the morphological alterations in the thymus. The results obtained might be taken as an evidence of the depression of cellular immunity in this group of animals.
研究了不同出生后早期个体发育阶段患有慢性胆汁淤积性肝损伤的雌性大鼠后代胸腺的结构功能变化。结果发现，与对照组相比，该组动物后代在研究的各个时期胸腺质量均较小，迟发型高敏免疫反应强度较低，E-RFC胸腺细胞数量较少。观察到的免疫变化与胸腺的形态学改变密切相关。所得结果可作为该组动物细胞免疫抑制的证据。
