Petrova T B
Arkh Anat Gistol Embriol. 1984 Feb;86(2):85-92.
Structural peculiarities of the thymus have been studied in Wistar rats during antenatal and early postnatal periods of ontogenesis under the effect of tetracycline hydrochlorid administered in therapeutic doses to the system mother--fetus during preimplantation period of the fetus development (the 1st - 6th days). Histological, histochemical, electron microscopical and morphometrical methods have been used. Ultrastructural changes of epithelioreticulocytes and thymocytes, a delayed appearance of the subcapsular zone, a delayed division of the thymus lobules into the cortex and medullar substance, a decreasing content of all cellular forms of the lymphoid line during the intrauterine development have been revealed, as well as a decreased amount of small lymphocytes at all stages of the antenatal and early postnatal periods of ontogenesis. The data obtained are considered as a result of a toxic effect of the antibiotic.
在胎儿发育的植入前期（第1 - 6天），给母 - 胎系统施以治疗剂量的盐酸四环素，在此条件下，运用组织学、组织化学、电子显微镜及形态计量学方法，对Wistar大鼠在产前及产后早期发育阶段胸腺的结构特点进行了研究。结果显示，上皮网状细胞和胸腺细胞的超微结构发生变化，被膜下区出现延迟，胸腺小叶分化为皮质和髓质延迟，宫内发育期间淋巴系所有细胞形式的含量减少，并且在产前和产后早期发育的各个阶段小淋巴细胞数量均减少。所获数据被认为是抗生素毒性作用的结果。
