Tajiri H, Nakano T, Kozaiwa K, Harada T, Okada S, Fushimi R, Amino N, Miyai K
Department of Pediatrics, Osaka University Hospital, Japan.
J Clin Lab Immunol. 1992;38(1):41-9.
We demonstrate immunoglobulin-complexed aspartate aminotransferase (macro-AST) in a 14-year-old boy with rectitis-type ulcerative colitis by using both gel filtration and electrophoresis methods. The immunoglobulin complexed with AST in this case was identified as an IgG kappa both by electrosyneresis and immunoprecipitation reactions. The present case was noted to have a concomitant elevation of macro-AST associated with deterioration of ulcerative colitis. However, macro-AST has continued to exist when the activity of ulcerative colitis subsided, and the serum level of AST became normal. Thus, macro-AST might be related to an immunological component of ulcerative colitis as well as to the activity of the disease.
我们通过凝胶过滤和电泳方法，在一名患有直肠炎型溃疡性结肠炎的14岁男孩体内证实了免疫球蛋白复合天冬氨酸转氨酶（巨AST）的存在。通过电致收缩和免疫沉淀反应，确定该病例中与AST复合的免疫球蛋白为IgG κ。本病例中巨AST升高与溃疡性结肠炎病情恶化相关。然而，当溃疡性结肠炎病情缓解时，巨AST仍然存在，且AST的血清水平恢复正常。因此，巨AST可能与溃疡性结肠炎的免疫成分以及疾病活动有关。
