Vandenbussche F, Bernard D, Orlent H
Dienst Maag-, Darm- en Leverziekten, Algemeen Ziekenhuis Sint-Jan, Ruddershove 10, 8000 Brugge, België.
Ned Tijdschr Geneeskd. 2005 Dec 10;149(50):2807-9.
A 23-year-old asymptomatic patient wanted to become pregnant and had a blood analysis done at her general practitioner's office. The serum aspartate aminotransferase (AST) level was unexpectedly elevated: 139 U/l (reference value: < 32). The values for the other liver enzymes were normal. Extensive biochemical and imaging studies revealed no other abnormalities. The presence of so-called macro-AST was suspected. In this condition, AST forms complexes with other proteins, primarily IgG, which leads to an increased serum level. This has no clinical consequences. The presence of such complexes was confirmed by means ofa polyethylene glycol precipitation assay. This is a simple test for the detection of macro-AST, which saves the asymptomatic patient further invasive diagnostic procedures.
一名23岁无症状患者想要怀孕,便在全科医生诊所进行了血液分析。血清天冬氨酸氨基转移酶(AST)水平意外升高:139 U/l(参考值:<32)。其他肝脏酶的值正常。广泛的生化和影像学研究未发现其他异常。怀疑存在所谓的巨AST。在这种情况下,AST与其他蛋白质(主要是IgG)形成复合物,这导致血清水平升高。这没有临床后果。通过聚乙二醇沉淀试验证实了此类复合物的存在。这是一种检测巨AST的简单试验,为无症状患者省去了进一步的侵入性诊断程序。