Caplan L S, Helzlsouer K J
Department of Preventive Medicine, State University of New York at Stony Brook 11974-8036.
Public Health Rev. 1992;20(3-4):187-214.
Delay in seeking medical attention for breast cancer symptoms, as well as delay in the diagnosing of and delivery of effective treatments for breast cancer may result in advanced states of disease, thereby contributing to breast cancer mortality. Our knowledge of the scope and characteristics of delay in breast cancer is limited. Delay can be divided into two components, patient and system delay. Patient delay is the time it takes for a women to seek help once she has discovered a breast symptom. System delay is the time it takes for a woman to be evaluated, diagnosed, and treated once she has sought help. Most of the studies have dealt with patient delay, with few studies being performed on system delay, especially in the United States. It is evident that patient and system delays of 2-3 months apiece do occur in a small percentage of cases. However, there is not a clear picture of the factors associated with these long delays. Studies have had conflicting results and have often been difficult to compare because of inconsistent definitions of delay. This review critically examines the available literature on delay in breast cancer. Given the lack of a complete understanding regarding the factors associated with long delay, and the fact that the earlier a breast cancer is diagnosed and treated, the greater the likelihood of long-term survival, it is especially important to do further work to determine the factors associated with long delay so that interventions can be designed to minimize delay and thus permit earlier diagnoses and treatments of breast cancers.
乳腺癌症状出现后寻求医疗关注的延迟,以及乳腺癌诊断和有效治疗交付的延迟,可能会导致疾病进展到晚期,从而导致乳腺癌死亡率上升。我们对乳腺癌延迟的范围和特征的了解有限。延迟可分为两个部分:患者延迟和系统延迟。患者延迟是指女性发现乳房症状后寻求帮助所需的时间。系统延迟是指女性寻求帮助后接受评估、诊断和治疗所需的时间。大多数研究关注的是患者延迟,对系统延迟的研究较少,尤其是在美国。显然,在一小部分病例中确实会出现患者延迟和系统延迟各达2至3个月的情况。然而,对于导致这些长时间延迟的相关因素,目前尚无清晰的认识。由于延迟的定义不一致,研究结果相互矛盾,且往往难以进行比较。本综述批判性地审视了关于乳腺癌延迟的现有文献。鉴于对导致长时间延迟的相关因素缺乏全面了解,而且乳腺癌诊断和治疗越早,长期生存的可能性就越大,进一步开展工作以确定导致长时间延迟的相关因素尤为重要,这样就可以设计干预措施来尽量减少延迟,从而实现乳腺癌的早期诊断和治疗。