Alsalameh S, Jerez R, Bujía J, Haeupl T, Kalden J R, Burmester G R
Departamento de Medicina III, Universidad Erlangen-Nuremberg, Munich, RFA.
Rev Med Chil. 1992 Dec;120(12):1400-10.
Cytokines and growth factors are important mediators of inflammatory reactions and play a central role in the physiologic regulation of bone and cartilage cell activities and in joint destruction. The net effects of cytokines on target tissues depend on the relative pericellular concentrations of several cytokines and their inhibitors in the inflammatory tissue. It is possible to suppress the effects of cytokines with natural or synthetic inhibitory molecules. The measurement of cytokines and their inhibitors may be useful to understand the pathogenesis and to develop new therapies for inflammatory joint diseases. In this review the following cytokines will be reviewed: interleukin 1 and its inhibitor, tumor necrosis factor alpha and its inhibitor, interleukin 6, interferon gamma, transforming growth factor beta, colony-stimulating factors, fibroblast growth factors, platelet derived growth factor and prostaglandins.
细胞因子和生长因子是炎症反应的重要介质，在骨和软骨细胞活动的生理调节以及关节破坏过程中发挥核心作用。细胞因子对靶组织的净效应取决于炎症组织中几种细胞因子及其抑制剂的相对细胞周围浓度。使用天然或合成抑制分子抑制细胞因子的作用是可能的。细胞因子及其抑制剂的检测对于理解炎症性关节疾病的发病机制和开发新疗法可能是有用的。在本综述中，将对以下细胞因子进行综述：白细胞介素1及其抑制剂、肿瘤坏死因子α及其抑制剂、白细胞介素6、干扰素γ、转化生长因子β、集落刺激因子、成纤维细胞生长因子、血小板衍生生长因子和前列腺素。
