Daoust M, Ernouf D, Narcisse G
Pharmacologie Médicale, UFR Médecine et Pharmacie, Saint-Etienne du Rouvray, France.
Ann Med Psychol (Paris). 1992 Feb-Mar;150(2-3):143-6.
There is considerable evidence from animal and human studies that serotonin plays a role in the modulation of alcohol intake and/or alcohol dependence. Biochemical, behavioral and pharmacological studies both in animal and man had verified this hypothesis. Central and peripheral levels of serotonin and of its metabolite 5-hydroxyindoleacetic acid (5-HIAA) are modified by alcoholisation. Moreover, the use of pharmacological drugs modifying specifically serotonin transmission decreases ethanol intake. Our own studies suggest that a dysfunctioning of serotonin uptake system could be implicated in the individual risk of alcohol dependence. Even if other systems, e.g. amino acids, are involved in the regulation of alcohol behavior, all data are in favor of a modulation of alcohol intake by serotonin transmission.
来自动物和人体研究的大量证据表明，血清素在调节酒精摄入和/或酒精依赖方面发挥着作用。动物和人类的生化、行为及药理学研究均证实了这一假设。酒精摄入会改变血清素及其代谢物5-羟吲哚乙酸（5-HIAA）的中枢和外周水平。此外，使用特异性改变血清素传递的药物会减少乙醇摄入。我们自己的研究表明，血清素摄取系统功能失调可能与个体酒精依赖风险有关。即使其他系统（如氨基酸）也参与酒精行为的调节，但所有数据均支持血清素传递对酒精摄入的调节作用。
