Sellers E M
Clinical Research and Treatment Institute, University of Toronto, Canada.
Alcohol Alcohol Suppl. 1994;2:517-21.
In devising pharmacological treatments for alcohol dependence, attention has to be directed to drugs which manipulate the neurobiological basis of ethanol's reinforcing properties and which do so with an acceptable margin of safety. This paper will review four main issues; the meaning of "craving", the role of serotonin in the neuroregulation of ethanol consumption and the effect of serotonergic drugs on ethanol intake, the role of other neurotransmitter systems, and how pharmacological treatments can be combined with psychosocial approaches.
在设计针对酒精依赖的药物治疗方法时，必须关注那些能够调控乙醇强化特性的神经生物学基础且具有可接受安全范围的药物。本文将综述四个主要问题：“渴望”的含义、血清素在乙醇消费神经调节中的作用以及血清素能药物对乙醇摄入量的影响、其他神经递质系统的作用，以及药物治疗如何与心理社会方法相结合。
