Cazard P, Ricard F, Facchetti L
C.N.R.S. UA 654, L.E.N.A. Hôpital de la Salpêtrière, Paris.
Ann Med Psychol (Paris). 1992 Feb-Mar;150(2-3):230-9.
A new quantified EEG index (Alpha Burst Occurrence Variability Index: alpha BVI) has been devised in order to characterize sequential variations of alpha bursts in EEG. This index makes it possible to quantify slope variations of a cumulative graph (periodogram) where the rank of alpha bursts is traced as a function of their instant of arrival. Such quantitative analysis was applied to spontaneous EEG segments which were recorded in the parieto-occipital regions (P3-Fz and P4-Fz) during a rest period, in three groups of depressed patients, one being characterized by psychomotor retardation (PRM group), another one by an emotional blunting (EB group) and a group of impulsive depressed patients (I group). The patients were compared to a group of healthy control subjects. In the three patient groups, before treatment, it was observed that the right and left alpha BVI were significantly lower than those of the control subjects. The right hemisphere was involved in all cases, but the left hemisphere was involved only in severe cases. In the EB and I groups, two strong "electro-clinical" correlations were observed, each one being specific for each hemisphere, one relating the reduction of the right alpha BVI to the depressive mood, the other relating the reduction of the left alpha BVI to the degree of speech ("ideoverbal") retardation. These results emphasize the role of the right hemisphere in the probable pathogenesis of depression.
为了描述脑电图（EEG）中α波爆发的连续变化，人们设计了一种新的定量脑电图指数（α波爆发发生率变异性指数：αBVI）。该指数能够量化累积图（周期图）的斜率变化，在该图中，α波爆发的顺序是根据其到达时刻进行追踪的。这种定量分析应用于三组抑郁症患者在休息期间顶枕区（P3 - Fz和P4 - Fz）记录的自发脑电图片段，一组以精神运动迟缓为特征（PRM组），另一组以情感迟钝为特征（EB组），还有一组冲动性抑郁症患者（I组）。将这些患者与一组健康对照受试者进行比较。在三组患者治疗前，观察到左右αBVI均显著低于对照受试者。所有病例中右侧半球均受累，但仅在严重病例中左侧半球受累。在EB组和I组中，观察到两种强烈的“电 - 临床”相关性，每种相关性在每个半球都具有特异性，一种将右侧αBVI的降低与抑郁情绪相关联，另一种将左侧αBVI的降低与言语（“观念性言语”）迟缓程度相关联。这些结果强调了右侧半球在抑郁症可能发病机制中的作用。
