Graae F, Tenke C, Bruder G, Rotheram M J, Piacentini J, Castro-Blanco D, Leite P, Towey J
Department of Child and Adolescent Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York, USA.
Biol Psychiatry. 1996 Oct 15;40(8):706-13. doi: 10.1016/0006-3223(95)00493-9.
Abnormal electroencephalographic (EEG) activity has been associated with various psychiatric disorders and behaviors, including depression, suicide, and aggression. We examined quantitative resting EEG in Hispanic female adolescent suicide attempters and matched normal controls. Computerized EEG measures were recorded at 11 scalp sites during eyes open and eyes closed periods from 16 suicide attempters and 22 normal controls. Suicide attempters differed from normal controls in alpha asymmetry. Normal adolescents had greater alpha (less activation) over right than left hemisphere, whereas suicidal adolescents had a nonsignificant asymmetry in the opposite direction. Nondepressed attempters were distinguished from depressed attempters in that they accounted for the preponderance of abnormal asymmetry, particularly in posterior regions. Alpha asymmetry over posterior regions was related to ratings of suicidal intent, but not depression severity. The alpha asymmetry in suicidal adolescents resembled that seen for depressed adults in its abnormal direction, but not in its regional distribution. Findings for suicidal adolescents are discussed in terms of a hypothesis of reduced left posterior activation, which is not related to depression but to suicidal or aggressive behavior.
异常脑电图（EEG）活动与多种精神疾病及行为有关，包括抑郁症、自杀和攻击行为。我们对西班牙裔女性青少年自杀未遂者和匹配的正常对照组进行了静息态脑电图定量研究。对16名自杀未遂者和22名正常对照者在睁眼和闭眼期间的11个头皮部位记录了计算机化脑电图测量值。自杀未遂者与正常对照组在α波不对称性方面存在差异。正常青少年右半球的α波（激活程度较低）比左半球更强，而自杀青少年的不对称方向相反且不显著。未患抑郁症的自杀未遂者与患抑郁症的自杀未遂者的区别在于，前者存在大量异常不对称，尤其是在后部区域。后部区域的α波不对称性与自杀意图评分有关，但与抑郁严重程度无关。自杀青少年的α波不对称性在异常方向上与抑郁成年人相似，但在区域分布上不同。根据左后激活减少的假说对自杀青少年的研究结果进行了讨论，该假说与抑郁症无关，而是与自杀或攻击行为有关。
