Cazard P, Pollak V, Jouvent R, Leboyer M, Grob R, Lesèvre N
C.N.R.S. UA 654: L.E.N.A. Hôpital de la Salpêtrière, Paris, France.
Int J Psychophysiol. 1989 Nov;8(2):169-83. doi: 10.1016/0167-8760(89)90006-8.
A new quantitative EEG index based on the sequential variability of the frequency of occurrence of alpha bursts (alpha-BVI) was utilized for investigating the respective role of the two hemispheres in depression and their relationship with two clinical dimensions of this illness: psychomotor retardation and blunted affect. The EEG (at P3 and P4 referred to Fz) was recorded during rest periods in two groups of patients selected according to their scores on various clinical scales: one consisted of 12 patients characterized by psychomotor retardation (PMR group), the other of 9 patients characterized by blunted affect (BA group). A control group of 12 normal subjects was recorded in the same conditions. All subjects were dextral. The following main results were obtained: (1) in both groups of patients the right and the left alpha-BVI were, before treatment, significantly lower than those of the controls. (2) In controls, the sequential alpha burst variability was identical on both hemispheres. (3) In patients, before treatment, the right hemisphere alpha-BVI was significantly lower than the left. (4) Electro-clinical correlations were also observed: (A) in the BA group, before treatment, (a) between the degree of blunted affect and the decrease of the right alpha-BVI, (b) between ideoverbal retardation and the decrease of the left alpha-BVI (these correlations disappeared after treatment); (B) in the PMR group, ideoverbal retardation was, on the contrary, correlated to a right alpha-BVI decrease, this correlation persisting after treatment. These results are discussed according to the role of each hemisphere in depression.
一种基于α波爆发频率序列变异性的新型定量脑电图指标（α-BVI）被用于研究两个半球在抑郁症中的各自作用以及它们与该疾病两个临床维度的关系：精神运动迟缓和平淡情感。在根据各种临床量表得分选择的两组患者的休息期间记录脑电图（P3和P4相对于Fz）：一组由12名以精神运动迟缓为特征的患者组成（PMR组），另一组由9名以平淡情感为特征的患者组成（BA组）。在相同条件下记录了12名正常受试者的对照组。所有受试者均为右利手。获得了以下主要结果：（1）在两组患者中，治疗前左右α-BVI均显著低于对照组。（2）在对照组中，两个半球的α波爆发序列变异性相同。（3）在患者中，治疗前右半球α-BVI显著低于左半球。（4）还观察到电-临床相关性：（A）在BA组中，治疗前，（a）平淡情感程度与右α-BVI降低之间，（b）言语思维迟缓与左α-BVI降低之间（这些相关性在治疗后消失）；（B）在PMR组中，相反，言语思维迟缓与右α-BVI降低相关，这种相关性在治疗后持续存在。根据每个半球在抑郁症中的作用对这些结果进行了讨论。
