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Spin-trapping of free radicals during phthalocyanine photosensitization of lymphoma cells in vitro.

作者信息

Gantchev T G

机构信息

Department for Cell and Molecular Biology of Cancer, National Centre of Oncology, Sofia, Bulgaria.

出版信息

Cancer Biochem Biophys. 1992 Nov;13(2):103-11.

PMID:1343848
Abstract

Spin-trapping and electron spin resonance (ESR) spectroscopy were used to detect free radicals generated during light exposure of lymphoma cells sensitized in vitro by metallotetrasulfophthalocyanines (Al-PcS4 and Zn-PcS4). 5,5-dimethyl-1-pyrroline-1-oxide (DMPO) and alpha-phenyl-beta-tert-butylnitrone (PBN) were used as spin-trapping agents. Hydroxyl radical spin-adducts were detected under conditions of both extracellular and intracellular photosensitization. In addition, organic radicals of different origin and/or variable yields were trapped, depending on the photosensitization conditions and the spin-trap used. For comparison, analogous experiments were carried out with another tumor-localizing photosensitizer, Photofrin II.

摘要

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