RUTENBURG A M, SONNENBLICK E, KOVEN I, APRAHAMIAN H A, REINER L, FINE J
J Exp Med. 1957 Jul 1;106(1):1-14. doi: 10.1084/jem.106.1.1.
Diffuse hepatic cirrhosis develops in rats on a choline-deficient diet within 300 days. Absorbable broad spectrum antibiotics added to the daily diet do not prevent the development of fatty infiltration, but they delay the development of cirrhosis for about 100 days more. Non-absorbable antibiotics added to the daily diet prevent the development of cirrhosis in most rats for as long as 750 days. The superiority of non-absorbable antibiotics to absorbable antibiotics excludes a systemic effect of the antibiotics and demonstrates that intestinal bacteria are largely, if not wholly, responsible for the cirrhosis in rats on a choline-deficient diet.
在胆碱缺乏饮食的大鼠中,300天内会发生弥漫性肝硬化。在日常饮食中添加可吸收的广谱抗生素并不能阻止脂肪浸润的发展,但它们会将肝硬化的发展延迟约100天。在日常饮食中添加不可吸收的抗生素可在长达750天的时间内防止大多数大鼠发生肝硬化。不可吸收抗生素相对于可吸收抗生素的优势排除了抗生素的全身作用,并表明肠道细菌在很大程度上(如果不是全部的话)是胆碱缺乏饮食大鼠肝硬化的原因。