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The Occurrence of Neoplasms in the Liver, Lungs, and Other Tissues of Rats as a Result of Prolonged Choline Deficiency.

作者信息

Copeland D H, Salmon W D

出版信息

Am J Pathol. 1946 Sep;22(5):1059-79.

PMID:19970900
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1934229/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1678/1934229/28b0d92103ca/amjpathol00508-0208-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1678/1934229/89de88af9d71/amjpathol00508-0198-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1678/1934229/eae389267283/amjpathol00508-0198-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1678/1934229/7e856f8a7ff6/amjpathol00508-0198-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1678/1934229/13ddb2efe1c3/amjpathol00508-0198-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1678/1934229/bf5ba0943f9a/amjpathol00508-0200-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1678/1934229/c54855c08520/amjpathol00508-0200-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1678/1934229/00c006ee7249/amjpathol00508-0200-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1678/1934229/615c5f0918ef/amjpathol00508-0200-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1678/1934229/f5c7ce0803c1/amjpathol00508-0202-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1678/1934229/d1c6d0988efe/amjpathol00508-0202-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1678/1934229/8fd8887e49cd/amjpathol00508-0202-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1678/1934229/4df037f6f532/amjpathol00508-0202-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1678/1934229/a1c00909a515/amjpathol00508-0204-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1678/1934229/59da3abf5d8f/amjpathol00508-0204-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1678/1934229/411ec3b674da/amjpathol00508-0204-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1678/1934229/61c423e7058d/amjpathol00508-0204-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1678/1934229/259583eedee8/amjpathol00508-0206-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1678/1934229/24d3a438e036/amjpathol00508-0206-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1678/1934229/e195765a809d/amjpathol00508-0206-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1678/1934229/b647ce7c0cbf/amjpathol00508-0206-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1678/1934229/4264f3678241/amjpathol00508-0208-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1678/1934229/41aeb246d948/amjpathol00508-0208-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1678/1934229/91c76188cd1f/amjpathol00508-0208-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1678/1934229/28b0d92103ca/amjpathol00508-0208-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1678/1934229/89de88af9d71/amjpathol00508-0198-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1678/1934229/eae389267283/amjpathol00508-0198-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1678/1934229/7e856f8a7ff6/amjpathol00508-0198-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1678/1934229/13ddb2efe1c3/amjpathol00508-0198-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1678/1934229/bf5ba0943f9a/amjpathol00508-0200-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1678/1934229/c54855c08520/amjpathol00508-0200-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1678/1934229/00c006ee7249/amjpathol00508-0200-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1678/1934229/615c5f0918ef/amjpathol00508-0200-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1678/1934229/f5c7ce0803c1/amjpathol00508-0202-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1678/1934229/d1c6d0988efe/amjpathol00508-0202-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1678/1934229/8fd8887e49cd/amjpathol00508-0202-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1678/1934229/4df037f6f532/amjpathol00508-0202-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1678/1934229/a1c00909a515/amjpathol00508-0204-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1678/1934229/59da3abf5d8f/amjpathol00508-0204-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1678/1934229/411ec3b674da/amjpathol00508-0204-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1678/1934229/61c423e7058d/amjpathol00508-0204-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1678/1934229/259583eedee8/amjpathol00508-0206-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1678/1934229/24d3a438e036/amjpathol00508-0206-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1678/1934229/e195765a809d/amjpathol00508-0206-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1678/1934229/b647ce7c0cbf/amjpathol00508-0206-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1678/1934229/4264f3678241/amjpathol00508-0208-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1678/1934229/41aeb246d948/amjpathol00508-0208-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1678/1934229/91c76188cd1f/amjpathol00508-0208-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1678/1934229/28b0d92103ca/amjpathol00508-0208-d.jpg

相似文献

1
The Occurrence of Neoplasms in the Liver, Lungs, and Other Tissues of Rats as a Result of Prolonged Choline Deficiency.长期胆碱缺乏导致大鼠肝脏、肺及其他组织肿瘤的发生。
Am J Pathol. 1946 Sep;22(5):1059-79.
2
The occurrence of neoplasms in the liver, lungs, and other tissues of rats as a result of prolonged choline deficiency.长期胆碱缺乏导致大鼠肝脏、肺及其他组织中肿瘤的发生。
Am J Pathol. 1946 Sep;22:1059-79.
3
Choline and hepatocarcinogenesis in the rat.
Adv Exp Med Biol. 1995;375:65-74. doi: 10.1007/978-1-4899-0949-7_6.
4
Effects of prolonged (1 year) choline deficiency and subsequent re-feeding of choline on 1,2-sn-diradylglycerol, fatty acids and protein kinase C in rat liver.长期（1年）胆碱缺乏及随后胆碱再喂养对大鼠肝脏中1,2 - 二酰基甘油、脂肪酸和蛋白激酶C的影响。
Carcinogenesis. 1995 Feb;16(2):327-34. doi: 10.1093/carcin/16.2.327.
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Synthesis of phosphatidylcholine by rat lung during choline deficiency.胆碱缺乏时大鼠肺中磷脂酰胆碱的合成
J Appl Physiol (1985). 1986 Dec;61(6):2040-4. doi: 10.1152/jappl.1986.61.6.2040.
6
Expression of phosphatidylethanolamine N-methyltransferase-2 is markedly enhanced in long term choline-deficient rats.
J Biol Chem. 1996 Feb 2;271(5):2839-43. doi: 10.1074/jbc.271.5.2839.
7
Diurnal changes in liver and plasma lipids of choline-deficient rats.胆碱缺乏大鼠肝脏和血浆脂质的昼夜变化
J Lipid Res. 1966 Jan;7(1):10-6.
8
[Content of total and esterified cholesterol in liver tissue and blood with chronic protein-choline deficiency].[慢性蛋白质-胆碱缺乏时肝脏组织及血液中总胆固醇和酯化胆固醇的含量]
Ukr Biokhim Zh. 1975 Mar-Apr;47(2):209-13.
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Accumulation of 1,2-sn-diradylglycerol with increased membrane-associated protein kinase C may be the mechanism for spontaneous hepatocarcinogenesis in choline-deficient rats.1,2-二酰基甘油的积累以及膜相关蛋白激酶C的增加可能是胆碱缺乏大鼠自发肝癌发生的机制。
J Biol Chem. 1993 Jan 25;268(3):2100-5.
10
New insight into the biochemical pathology of liver in choline deficiency.胆碱缺乏时肝脏生化病理学的新见解。
Crit Rev Biochem Mol Biol. 1995;30(4):263-73. doi: 10.3109/10409239509083487.

引用本文的文献

1
[About the appearance of multiple adenomas in the liver of rats fed low in choline].[关于喂食低胆碱饲料的大鼠肝脏中多发性腺瘤的出现]
Experientia. 1948 Apr 15;4(6):233. doi: 10.1007/BF02155379.
2
Effect of choline on experimental carcinogenesis.胆碱对实验性致癌作用的影响。
Br J Cancer. 1949 Dec;3(4):557. doi: 10.1038/bjc.1949.61.
3
[Slit-lamp microscopy and ophthalmoscopy in rat and mouse].[大鼠和小鼠的裂隙灯显微镜检查和检眼镜检查]

本文引用的文献

1
THE PREVENTION BY CHOLINE OF LIVER CIRRHOSIS IN RATS ON HIGH FAT, LOW PROTEIN DIETS.胆碱对高脂低蛋白饮食大鼠肝硬化的预防作用
Science. 1941 Jun 20;93(2425):598-9. doi: 10.1126/science.93.2425.598.
Doc Ophthalmol. 1951;5-6:452-554. doi: 10.1007/BF00143667.
4
Pathogenesis of the cirrhosis produced by choline deficiency; escape of lipid from fatty hepatic cysts into the biliary and vascular systems.胆碱缺乏所致肝硬化的发病机制；脂质从脂肪肝囊肿逸入胆道和血管系统。
Am J Pathol. 1951 Nov-Dec;27(6):951-89.
5
The role of intestinal bacteria in the development of dietary cirrhosis in rats.肠道细菌在大鼠饮食性肝硬化发展中的作用。
J Exp Med. 1957 Jul 1;106(1):1-14. doi: 10.1084/jem.106.1.1.
6
Primary carcinomas of the liver and biliary tract.肝脏和胆道原发性癌
Br J Cancer. 1956 Jun;10(2):232-46. doi: 10.1038/bjc.1956.27.
7
The intracellular metabolism of 3:4 benzpyrene; studies of rat liver subjected to repeated doses of benzpyrene.3,4-苯并芘的细胞内代谢；对反复给予苯并芘的大鼠肝脏的研究。
Br J Cancer. 1955 Sep;9(3):426-33. doi: 10.1038/bjc.1955.41.
8
Senecio alkaloids; primary liver tumours in rats as a result of treatment with (1) a mixture of alkaloids from S. jacobaea Lin.; (2) retrorsine; (3) isatidine.千里光生物碱；大鼠原发性肝肿瘤，由以下物质处理所致：（1）来自欧洲千里光的生物碱混合物；（2）倒千里光碱；（3）异阿替丁。
Br J Cancer. 1954 Sep;8(3):458-65. doi: 10.1038/bjc.1954.49.
9
[Primary carcinoma of the liver in Basel from 1937-1952].[1937年至1952年巴塞尔原发性肝癌]
Z Krebsforsch. 1954;60(1):115-38.
10
Primary carcinoma of the liver: description of a case with ethanolaminuria, a new and obscure metabolic defect.原发性肝癌：一例伴有乙醇胺尿症（一种新的、不明的代谢缺陷）病例的描述。
Br J Cancer. 1953 Jun;7(2):166-80. doi: 10.1038/bjc.1953.16.