Ichikawa Y, Tokunaga N, Kinoshita M, Yano T, Oizumi K
First Department of Internal Medicine, Kurume University School of Medicine, Fukuoka, Japan.
Sarcoidosis. 1992 Mar;9(1):60-6.
We describe two patients demonstrating a granulomatous inflammation of bronchial mucosa characterized clinically by a persistent dry cough, lack of manifestations of bronchial asthma, normal level of serum IgE and serum ACE, inflamed bronchial mucosal appearance consisting of edema, erythema, bleeding and narrowing and recovering without specific treatment. Histopathological findings of the bronchial inflammation of our patients were characterized by noncaseating granuloma formation consisting of epithelioid cells and multinucleated giant cells with infiltration of lymphocytes, plasma cells and eosinophils. The bronchial granulomatous inflammation of our patients was thought to differ from that of diseases which have been known, to our knowledge, as diseases demonstrating a granulomatous inflammation of bronchial mucosa. Although the pathogenesis of the disease could not be clarified by a careful search of special staining and culturing for the infective agent, it was most suggestive of non-specific inflammation with a granulomatous response to some sort of inhaled agents.
我们描述了两名患者，其表现为支气管黏膜的肉芽肿性炎症，临床特征为持续性干咳、无支气管哮喘表现、血清IgE和血清ACE水平正常、支气管黏膜外观呈炎症改变，包括水肿、红斑、出血和狭窄，且未经特殊治疗即可恢复。我们患者支气管炎症的组织病理学表现为非干酪样肉芽肿形成，由上皮样细胞和多核巨细胞组成，并伴有淋巴细胞、浆细胞和嗜酸性粒细胞浸润。据我们所知，我们患者的支气管肉芽肿性炎症被认为与已知的表现为支气管黏膜肉芽肿性炎症的疾病不同。尽管通过仔细寻找感染因子的特殊染色和培养未能阐明该疾病的发病机制，但最有可能提示为对某种吸入剂的肉芽肿反应性非特异性炎症。
