Kortsik C S, Schneider C G, Staedt U, Filser T, Bohrer M, Saeger K D
Medizinische Klinik, Fakultät der Universität Heidelberg.
Dtsch Med Wochenschr. 1988 Sep 9;113(36):1394-6. doi: 10.1055/s-2008-1067825.
In a 47-year-old man presenting with chronic bronchitis since 1978, a weight loss of 11 kg in 9 months and deteriorated general condition, the x-ray film of the thorax revealed numerous pulmonary nodules of up to 4 cm size. Laboratory findings were characterised by enhanced ESR, blood eosinophilia of 7% and a lot of eosinophilic granulocytes in the sputum. The findings could not be clarified despite many additional examinations including bronchoscopy with transbronchial biopsy. Thoracotomy was finally considered imperative. Pulmonary biopsy revealed necrotising vasculitis, eosinophilic infiltration and epithelioid granuloma, characteristic changes of allergic granulomatous vasculitis (Churg-Strauss syndrome). The condition quickly responded to corticosteroid administration.
一名自1978年起患有慢性支气管炎的47岁男性，在9个月内体重减轻了11公斤，全身状况恶化，胸部X光片显示有多个大小达4厘米的肺结节。实验室检查结果的特征是血沉加快、血液嗜酸性粒细胞增多至7%，痰液中有大量嗜酸性粒细胞。尽管进行了包括支气管镜检查及经支气管活检在内的许多其他检查，这些发现仍无法得到明确诊断。最终认为必须进行开胸手术。肺活检显示坏死性血管炎、嗜酸性粒细胞浸润和上皮样肉芽肿，这是变应性肉芽肿性血管炎（Churg-Strauss综合征）的特征性改变。该病情对皮质类固醇治疗反应迅速。
