Mukherjee D
N.R.S. Medical College, Calcutta.
Indian J Pathol Microbiol. 1992 Jul;35(3):241-6.
Isosorbide dinitrate was tried in 27 patients of acute myocardial infarction (AMI) with the purpose of reduction of infarction size. Overall average effect was not significant. But, it was found that, the small and moderate "predicted infarction size" (PIS) group of patients, were benefitted by the drug therapy. Effectiveness in the therapeutic intervention on ischaemic injury bore an inverse relation with the degree of PIS or the "risk region". Varying "risk region" may be an important factor responsible for the apparent discrepancy between results of different workers regarding therapeutic intervention of infarction size.
对27例急性心肌梗死（AMI）患者试用了硝酸异山梨酯，目的是缩小梗死面积。总体平均效果不显著。但是，发现小面积和中等面积“预测梗死面积”（PIS）组的患者从药物治疗中获益。对缺血性损伤的治疗干预效果与PIS程度或“危险区域”呈负相关。不同的“危险区域”可能是不同研究者在梗死面积治疗干预结果方面存在明显差异的一个重要因素。
