小鼠中镇静与体温之间的关系。
The relation between sedation and body temperature in the mouse.
作者信息
LESSIN A W, PARKES M W
出版信息
Br J Pharmacol Chemother. 1957 Jun;12(2):245-50. doi: 10.1111/j.1476-5381.1957.tb00128.x.
Abstract
Chlorpromazine and reserpine reduce locomotor activity and prolong pentobarbitone hypnosis in mice. Both these effects are shown to be proportional to the fall in body temperature produced by these drugs. Other agents are shown to reduce body temperature and potentiate pentobarbitone. At ambient temperatures of 32 degrees C. neither chlorpromazine nor reserpine is hypothermic or sedative. It is concluded that sedative effects in the mouse at ordinary room temperatures are related to the hypothermic properties of these drugs. At 36 degrees C., while reserpine fails to potentiate pentobarbitone, chlorpromazine still does so.
摘要
氯丙嗪和利血平可降低小鼠的自发活动，并延长戊巴比妥引起的小鼠睡眠时间。这两种作用均与这些药物引起的体温下降成正比。其他药物也可降低体温并增强戊巴比妥的作用。在32摄氏度的环境温度下，氯丙嗪和利血平均不会引起体温过低或产生镇静作用。由此得出结论，在常温下，小鼠的镇静作用与这些药物的降温特性有关。在36摄氏度时，利血平不能增强戊巴比妥的作用，而氯丙嗪仍能增强其作用。
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